AX01 Polynucleotide Hydro-Structural Serum

AX01

Polynucleotide Hydro-Structural Serum

A rare, lightweight yet ultra-hydrating serum designed to support the skin's intrinsic biological recovery mechanisms. Refines skin texture and smooths fine lines. Swift absorption technology delivers a clean, elegant finish.

Formulated with single-origin polydeoxyribonucleotide (PdRN), a fibroblast stimulating agent, at 20,000 ppm. The high concentration of copper tripeptide, known for its wound healing properties, gives the serum its deep sea hue.

Made with post-procedure skin in mind. Suitable for daily use for stressed or sensitized skin, including after aesthetic treatments.

$360.00 30 ml
First production, 2026
Recommended for
  • +All skin types, including sensitive
  • +Skin in recovery, après-derma
  • +Fine lines around the eyes and mouth
Protocol

Apply 1-2 full drops to clean face and neck, morning and evening. Gently massage until absorbed. Finish with cream.

Core ingredients

The primary regenerative complex (PdRN) in AX01 is derived from independently farmed sushi-grade salmon. Our partner lab oversees every stage of cultivation, extraction and refinement to ensure purity, consistency and traceability.

PdRN · 20,000 PPM Salmon-derived DNA fragments that encourage cellular regeneration and dermal repair
SALMON ROE Contains skin-nourishing omega-3 fatty acids, vitamins A & E and astaxanthin
CAVIAR Abundant in amino acids and phospholipids that firm the skin and deeply hydrate
CENTELLA LEAF Reduces inflammation and provides barrier protection
GLUTATHIONE An antioxidant peptide that neutralizes free radicals and evens skin tone
COPPER TRIPEPTIDE-1 A signaling peptide that supports the skin’s natural repair system
Clinical testing

Third-party clinical testing of AX01’s single-origin PdRN solution after 4 weeks of consistent use

Parameter Change
Dermal densityHigh-frequency ultrasound +51%
Depth of periorbital wrinkles3D skin imaging · multi-wavelength LED −27%
Lifting of facial contour3D skin imaging +23%
Depth of nasolabial folds3D skin imaging −21%†
Surface skin hydrationTissue dielectric constant +13%
Deep skin hydrationTissue dielectric constant +11%
Skin elasticitySuction cutometry +11%
Brightness of skin toneTristimulus colorimetry +6%
n = 21, women aged 46 to 59, measured on the face before and after four weeks of use. All parameters significant at p < 0.001, paired t-test, †Wilcoxon signed-rank.
In the laboratory
01Cell migration
In a scratch wound-healing assay, higher concentrations of AX01 single-origin PdRN resulted in faster skin cell migration for repair.
02Inflammatory markers
With increasing concentration of PdRN, the proteins that inflame skin and degrade collagen decrease, measured by quantitative PCR. AX01 is formulated at the maximum soluble PdRN concentration of 20,000 ppm.
On skin
03Tone and texture
BeforeAfter
After 2 weeks of use, skin becomes visibly calmer and smoother.
04Periorbital wrinkles
BeforeAfter
3D skin imaging of the periorbital area before and after 4 weeks of use. Red indicates deep-set lines; yellow indicates fine lines.
05Nasolabial folds
BeforeAfter
3D skin imaging of the nasolabial fold before and after 4 weeks of use. Red indicates deep-set lines; yellow indicates fine lines.
06Dermal density
BeforeAfter
High-frequency ultrasound of the dermis before and after 4 weeks of use.

Every batch is tested for virus inactivation and endotoxin removal.

Science

AX01 is powered by polydeoxyribonucleotide (PdRN), a bioactive compound derived from the sperm cells of salmon. In skin, PdRN calms visible redness and supports the natural renewal of the dermal matrix.

Skin aging is driven in part by a decline in cellular turnover and barrier function, and by DNA damage that accumulates as repair grows less efficient, leaving skin duller and less elastic.

Mechanistically, PdRN supplies nucleotides through the salvage pathway and selectively engages the adenosine A2A receptor, activating ERK / MAPK signaling to drive fibroblast proliferation, migration and collagen synthesis.

HDF wound-healing assay: migrated cells versus PdRN concentration
Human dermal fibroblast migration increased dose-dependently with PdRN in a wound-healing assay. Shin SM, Baek EJ, Kim KH, Kim KJ, Park EJ. Mol Med Rep. 2023;28(2):148. doi:10.3892/mmr.2023.13035. Reproduced under CC BY-NC-ND 4.0.

PdRN also tempers UV-driven pigmentation. Paired with niacinamide and glutathione, it helps buffer the hyperpigmentation, uneven tone and textural change that follow UV exposure.

Fontana-Masson histology of UV-exposed skin treated with a PdRN combination
Fontana-Masson staining: a niacinamide and PdRN combination reduced UV-induced melanin in skin. Park HJ, Byun K-A, Oh S, Kim HM, Chung MS, Son KH, Byun K. Molecules. 2022;27(15):4923. doi:10.3390/molecules27154923. Reproduced under CC BY 4.0.
Composition

Maris Aqua (Sea Water), Hippophae Rhamnoides Fruit (Sea Buckthorn) Extract, Salmon Ovum Extract, Centella Asiatica Leaf Extract, Crithmum Maritimum (Sea Fennel) Extract, Algae Extract, Niacinamide, Sodium Hyaluronate, 1,2-Hexanediol, Sodium DNA (PdRN), Caviar Extract, Artemisia Princeps Leaf (Mugwort) Extract, Linum Usitatissimum Seed (Linseed) Extract, Glutathione, Allantoin, Copper Tripeptide-1, Panthenol, Squalane, Sodium Benzoate, Potassium Sorbate, Carnosine, Ethylhexylglycerin.

Free of artificial fragrance, parabens, phthalates, silicones, mineral oil, PEG/PPG, colorants, petrolatum and phenoxyethanol. Cruelty-free.

Packaging

30 mL glass bottle. Rubber and glass dropper with aluminum neck. Fully recyclable.

“The color and texture are so elegant. As for the results: my face is glowing.”

- S., Paris
20,000PPM SINGLE-ORIGIN PdRN
0FRAGRANCE · PARABENS · SILICONES
Après-dermaMADE FOR SKIN IN RECOVERY
AX01 | Made in Korea